Late Biological Effect of High-dose Radiation in the Mice

Kim, Sung-ho; Kim, Young-ju; Oh, Yeong-ran; Yun, Taik-koo

Korean Journal of Veterinary Research 1987;27(2):269-275.

Sung-ho Kim, Young-ju Kim, Yeong-ran Oh, Taik-koo Yun

Laboratory of Cancer Pathology, Korea Cancer Center Hospital, Korea Advanced Energy Research Institute

마우스에서의 고선량(高線量) 방사선(放射線)에 의한 만성장해(慢性障害)

김성호, 김영주, 오영란, 윤택구

한국에너지연구소 원자력병원 암병리학연구실

Abstract

Radiation-induced life shortening, carcinogenesis and other pathological changes were investigated in NIH(GP) mice after $^{60}Co-{gamma}$ ray irradiation(100~700rads). The results were summarized as follows: 1. There were little difference in body weights, hematological examination and other clinical findings between normal and irradiated groups. 2. Mean survival time of the mice after irradiation were decreased dose-dependently. 3. Main gross findings of the mice irradiated were appeared as enlargement of spleen, thymus and lymph nodes, tumorous nodules of lung and cyst of ovary. Especially, enlargement of thymus was promineort in high dose group. 4. Microscopically, there were various findings including myeloid leukemia, thymic lymphoma, lung adenoma, adenosquamous cell carcinoma of pancreas, pneumonia and other pathological changes. Especially thymic lymphoma was highly frequent in the 700 rads group.