| Study on mechanism of multistep hepatotumorigenesis in rat : Bio-indices on hepatic tumorigenesis |
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Chung-boo Kang1, Chi-kyeong Kim1, Seung-hee Song1, Woo-song Ha2 |
1Department of Internal Medicine, College of Veterinary Medicine(Institute of Animal Medicine)
2Department of Surgery, College of Medicine, Gyeongsang National University |
| 간암의 다단계 발생기전에 관한 연구: 종양형성 과정에서의 생체지표 |
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강정부1, 김지경1, 송승희1, 하우송2 |
1경상대학교 수의과 대학(동물의학 연구소)
2경상대학교 의과대학 |
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| Abstract |
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To estalish bio-indices for detection of the development of multistep hepatotumorigenesis, rats were fed water containing 0.01% diethylnitrosamine (DEN) ad libitum for 13-14 weeks. Hepatocellular carcinoma was developed by treatment with DEN, DEN only was able to induce hepatic tumors in rats without any other cocarcinogen. Compared to control group, liver cytosol protein concentration in all treated grous was significantly decreased (p<0.05). From week to week, $20{alpha}$-hydroxysteroid dehydrogenase ($20{alpha}$-HSD) activity was increased and the highest activity was observed on the 12th week (p<0.05). In addition, the urine biopterin concentration was also significantly increased compared to control groups (p<0.05) in a time course manner. These results indicated that $20{alpha}$-HSD activity, urine biopterin and liver cytosol protein concentration might be very useful maker to hepatic tumorigenesis. |
| Key Words:
diethylnitrosamine, tumorigenesis, liver cytosol protein, $20{alpha}$-HSD activity, biopterin, rat |
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