| Dysmyelopoiesis in a cat with immune-mediated hemolytic anemia |
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Do-Hyeon Yu, Jong-Hyun Lee, Ji-Seon Yoon, Ying-Hua Li, Mi-Jin Lee, Jinho Park |
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College of Veterinary Medicine & Bio-Safety Institute, Chonbuk National University |
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| Abstract |
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A 3-year-old spayed female Persian feline with non regenerative anemia showed persistent autoagglutination in EDTA anticoagulated blood. Primary immune-mediated hemolytic anemia (IMHA) was suspected and the underlying causes for IMHA were excluded by radiologic, sonographic, serologic and molecular studies. Cytologic examination of the bone marrow revealed that dysmyelopoiesis and dysplastic changes were prominent in the erythroid cells. These changes included asynchronous maturation of the nucleus and cytoplasm, binucleation, trinucleation, fragmented or lobulated nuclei and multilineages. Mild dysgranulopoiesis and dysmegakaryocytopoiesis were also detected including pseudo Pelger-Huet anomalies, giant band neutrophils, asynchronous maturation of the nucleus and cytoplasm in granulopoiesis and large hypolobulated forms as well as dwarf megakaryocytes in megakaryocytopoiesis. Myelodysplastic syndrome and congenital dysmyelopoiesis was ruled out by the low number of blast cells. Finally, secondary dysmyelopoiesis associated with IMHA was diagnosed and immunosuppressive treatment was successfully responsive. |
| Key Words:
autoagglutination, dysmyelopoiesis, immune-mediated hemolytic anemia, myelodysplastic syndrome |
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