| Subacute toxicological study of PG102, a water-soluble extract derived from Actinidia arguta, in SD rats |
|
Eun-Sil Hong1, Mi-Jeong Kim1, Eun-Jung Kwon1, Lihong Kim1, Dong-Hyun Kim2, Hae-Kwan Eo1, Eun-Jin Park1, Sunyoung Kim2, Seon-Hee Kim1 |
1Biotechnology Incubating Center, Helixir Co.
2College of Biological Sciences, Seoul National University |
| 다래(Actinidia arguta) 열매의 열수 추출물, PG102의 4주 반복 경구투여에 대한 안전성 연구 |
|
홍은실1, 김미정1, 권은정1, 김리홍1, 김동현2, 어해관1, 박은진1, 김선영2, 김선희1 |
1헬릭서
2 |
|
|
| Abstract |
|
It was previously found that PG102, a water-soluble extract derived from Actinidia arguta, was able to modulate Th1/Th2 pathways and suppress IgE production resulting in dramatic amelioration of atopic dermatitis in NC/Nga mouse and hairless rat models. In order to evaluate the subacute toxicity of PG102, female and male SD rats were daily fed with various doses of PG102 for 4 weeks. Six week old SD rats were randomly divided into 4 groups and orally administrated with 100-, 300-, and 1,000- mg/kg of PG102 as well as the vehicle only. At the end of the study, no significant differences in the body and organ weights were observed between control and treated rats of both genders. Hematological and blood chemical analysis showed little differences between the animal groups. Neither gross abnormalities nor histopathological changes were found. PG102 produced little or no subacute toxicity and could be used as a safe nutraceutical for the treatment of individuals with allergic diseases including atopic dermatitis. |
| Key Words:
Actinidia arguta, allergy, complete blood cell counts, PG102, toxicity |
|
PDF Links
Full text via DOI
Download Citation
