Comparison of the safety and immunogenicity of commercial S. gallinarum 9R vaccine

Hwang, Jei Kiun; Lee, Young Ju

Korean Journal of Veterinary Research 2009;49(2):127-133.

Jei Kiun Hwang, Young Ju Lee

College of Veterinary Medicine, Kyungpook National University

국내 시판 Salmonella gallinarum 9R vaccine의 안전성 및 면역원성 비교

황제균, 이영주

경북대학교 수의과대학

Abstract

Salmonella enterica subsp. enterica serovar gallinarum (S. gallinarum) is the agent of fowl typhoid, and the 9R vaccine is a commercial live vaccine for the prevention of fowl typhoid. The aim of this study was to assess the safety and immunogenicity of different brands of S. gallinarum 9R vaccine used in commercial laying chickens in Korea. All 9R strains originated from three different brands showed the same pattern in the biochemical and serological properties, and pulsed field gel electrophoresis (PFGE) profile. But, there was a difference in rhamnose fermentaion, agglutination with Salmonella group $D_1$ antiserum and PFGE pattern between 9R vaccine strain and field S. gallinarum isolates. In laboratory and field trials for assesment of safety and immunogenicity of 9R vaccine, all of the three 9R vaccines showed the same safety in commercial laying chickens. In addition, there was a significant difference between the vaccinated and unvaccinated control groups in mortality and the re-isolation rate of the challenge strain from the tissues (p < 0.05), and no difference by the brands of 9R vaccine. The results from this study indicated that all three different brands of S. gallinarum 9R vaccine showed highly protection against mortality and organ invasion in commercial laying chickens exposed to virulent strains of S. gallinarum.

Key Words: immunogenicity, 9R vaccine, safety, Salmonella gallinarum