Immunological relationships of FMD vaccine strain and Asia1 field isolate from East Asia

Park, Jong-Hyeon; Ko, Young-Joon; Kim, Su-Mi; Lee, Hyang-Sim; Lee, Kwang-Nyeong; Cho, In-Soo

Korean Journal of Veterinary Research 2009;49(3):221-229.

Jong-Hyeon Park, Young-Joon Ko, Su-Mi Kim, Hyang-Sim Lee, Kwang-Nyeong Lee, In-Soo Cho

Foreign Animal Disease Division, National Veterinary Research and Quarantine Service

동아시아 유래 구제역바이러스 Asia1혈청형과 백신항원의 면역학적 상관성

박종현, 고영준, 김수미, 이향심, 이광녕, 조인수

국립수의과학검역원 해외전염병과

Abstract

Foot-and-mouth disease (FMD) is the most contagious disease of mammals. The use of inactivated vaccine can be chosen to prevent or control FMD. However, vaccination against one serotype of FMDV doses not cross-protect against other serotypes and may not protect fully against some strains of the same serotype. Appropriate selection of vaccine strain is an important element in the control of FMD. The immunity of vaccine antigens should be matched against newly circulating viruses. The phylogenetic analysis of serotype Asia1 reported from China, Mongolia, North Korea and Russia since 2005 shows that they are all classified into genetic group V, but the strain, Asia1/Shamir (ISR/89) which have been used as a vaccine strain in Korea, is clustered into different genetic group. So, in this study the serological relationship between the isolate (Asia1/MOG/05; MOG) and the Shamir strain was determined by ELISA and virus neutralization test. Even though the matching value of the virus (MOG) against the vaccinated sera in target animals was not so high, the vaccinated animals elicited antibodies enough for protection after vaccinated once or twice. Conclusively, we suggest that the vaccine containing Asia1/Shamir antigen could protect the genetic group V strains circulating in East Asia currently if vaccinated twice or the more.

Key Words: ELISA, FMD vaccine, neutralization, vaccine matching