| Protective effect of Hizikia fusiforme on radiation-induced damage in splenocytes |
|
Areum Kim1, So Jin Bing2, Jinhee Cho2, Ginnae Ahn3, Ji-Hyeok Lee4, You-Jin Jeon4, Byung-Gul Lee5, Youngheun Jee1 |
1Department of Advanced Convergence Technology & Science, Jeju National University
2Department of Veterinary Medicine, Jeju National University
3Department of Marine Bio-Food Sciences, Chonnam National University
4Department of Marine Life Sciences, Jeju National University
5Department of Civil Engineering, Jeju National University |
| 방사선을 조사한 마우스에서 비장세포에 대한 톳의 보호 작용 |
|
김아름1, 빙소진2, 조진희2, 안긴내3, 이지혁4, 전유진4, 이병걸5, 지영흔1 |
1제주대학교 차세대융복합과학기술협동과정
2제주대학교 수의과대학 수의학과
3전남대학교 수산해양대학 해양바이오식품학과
4제주대학교 해양과학대학 해양생물자원이용공학연구실
5제주대학교 토목공학과 |
|
|
| Abstract |
|
The immune system is specifically sensitive to oxidative stress induced by ionizing radiation because of its rapid proliferative activity. For this reason, an instructive immune system is one of the best ways to minimize side effects, such immunodeficiency, of gamma radiation. Over the past few decades, several natural plants with antioxidant and immunomodulatory properties have been identified as adjuncts for nontoxic and successful radiotherapy. Hizikia fusiforme extract (HFE) containing plentiful dietary fiber and fucoidan is known for its instructive antioxidant capacity, immunomodulation abilities, and immune activation. In this study, we determined whether HFE protects radiosensitive immune cells from gamma radiation-induced damage. C57BL/6 mice were irradiated with gamma-ray. The effect of HFE on the ionizing radiation damage of immune cells was then evaluated with an MTT assay, 3H-thymidine incorporation assay, and PI staining. We found that HFE stimulated the proliferation of gamma-ray irradiated immune cells without cytotoxic effects. We also observed that HFE not only decreased DNA damage but also reduced gamma radiation-induced apoptosis of the immune cells. Our results suggest that HFE can protect immune cells from gamma-ray damage and may serve as an effective, non-toxic radioprotective agent. |
| Key Words:
gamma-ray, Hizikia fusiforme, immune cell, natural functional product, oxidative stress |
|
PDF Links
Full text via DOI
Download Citation
